Endocrine Abstracts

Background: Multiple studies have shown that approximately 50-70% of patients with MEN1 die of causes directly related to MEN1 particularly gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). While non-functional GEP-NETs are the most common in the general population, gastrinomas (40%) are the most common functional GEP-NETs in patients with MEN1. c-Met is a proto-oncogene that encodes for c-MET, a tyrosine kinase receptor which promotes tumor cell motility, proliferati...

The Androgen Receptor (AR) is a ligand dependent transcription factor that regulates the development and maintenance of the male reproductive system. Previous studies in AIS have demonstrated ligand binding domain mutations resulting in decreased trans-activation activity through reduced N-terminal/C-terminal interaction of the AR, despite unaltered ligand binding ability.We have introduced mutations in the hinge region of the Androgen Receptor (AR) and assessed the effect...

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Introduction: Steatosis has become an important issue in hepatitis C, due to the injury it can cause in a chronically ill liver. In chronic hepatitis C patients, the prevalence of steatosis ranges from 40–86%. Steatosis was significantly associated with the lack of response using PEG-IFN and ribavirin. The aim of our study was to determine the prevalence of hepatic steatosis in chronic hepatitis C and determine its impact on the therapeutic response using new direct antiv...

G protein-coupled receptors play key roles in cell-cell communication processes, and, not surprisingly, are the main targets for therapeutic drugs. Among these, those of the class C are the receptors for neurotransmitters, glutamate and GABA (mGlu and GABABRs), for the umami and sweet taste compounds (T1Rs), and for calcium and basic amino acids (CaSR and GPRC6a). Class C GPCRs are much more complex proteins than the class A and B GPCRs. They are made of two subunit...

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

IntroductionChronic hepatitis C (CHC) is associated with an increased incidence of insulin resistance and diabetes mellitus. Obesity and insulin resistance are associated with faster progression of fibrosis in these patients. The aim of our study was to assess the impact of diabetes on the severity of hepatic fibrosis in patients followed for CHC.MethodsThis is a retrospective study conducted between January ...

Natriuretic peptides are a family of vasoactive mediators that play fundamental roles in the regulation of blood volume, blood pressure and cardiac integrity. The physiological and pathological functions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in the context of cardiovascular homeostasis are well-characterised. There is much less clarity with respect to C-type natriuretic peptide (CNP) which, in contrast to its cardiac-derived siblings, is predo...

Aim: The aim of this study was to investigate the role of C-reactive protein (CRP) in gestational diabetes mellitus.Material and methods: We studied 65 healthy pregnant women aged 29.75±5.59 years. All women referred for a 100–g oral glucose tolerance test following an abnormal result on a screening. The demographic data, waist circumference, height, and weight of the participants were recorded. Fasting levels of insulin, triglycerides (TG), CR...

In Ukraine, in 2017, an estimated 53000 people were living with chronic hepatitis C virus (HCV) infection, and its prevalence rate was 123.7 patients per 100000 citizens. Symptoms of at least one extra hepatic manifestations appear in more than 50% of HCV-positive patients, and thyroid abnormalities are rather common. The purpose of the study was to determine the prevalence of thyroid function tests and anti-thyroid autoantibodies abnormalities in the untreated patients with c...